ABSTRACT
Objective To observe effects of hydroxyethyl starch(130/0.4,voluven)on tissue perfusion and serum TNF-α,IL-6,IL-8 levels in patients with severe acute pancreatitis(SAP).Methods 60 SAP patients with non-operative treatment were randomly divided into voluven group and Ringer's solution group(n =30 per group).In addition to conventional drugs and treatment,of which voluven group daily 15ml/kg intravenously for 5 d;Ringer's solution group daily 20ml/kg intravenously for 5d.Hemodynamic parameters and tissue perfusion indicators were monitored,TN F-α,IL-6,IL-8 levels were examined after treatment 0,12,24,48,96 hours.Results Compared with Ringer solution group,Voluven group therapy high efficiency,faster raise MAP,ScvO2,Phi value,lower HR,Hct(t =2.785,3.126,4.132,3.168,2.218,all P ＜ 0.05).TNFα,IL-6 after 48h treatment,IL-8 after 96h treatment,both groups were significantly decreased,but the voluven group was significantly lower than Ringer's solution group(P ＜ 0.05).Conclusion Voluven could effectively and quickly maintain hemodynamic stability,improve the hemorheological and tissue perfusion,could be more conducive to improving the pancreatic microcirculation,thus inhibiting inflammatory cytokines TNF-α,IL-6,IL-8 release,and had favorable treatment effect on patients with SAP.
ABSTRACT
Objective To explore the effect of glycine on the intestinal barrier of rats with obstructive jaundice.Methods The male Wistar rats weighing 220—260g were randomly assigned to three groups(n=20): sham operation group(A),common bile ligation gruop(B),common bile duct ligation plus glycine group(C).Except sham operation group(A),rat models with obstructive jaundice in the other groups were set up by double ligation of the common bile duct.The rats in group C was fed with 5% glycine solution for 5 d.From the second day after the operation,the rats in group C were fed according to the preoperative standard.On the 21th day after operation,the rats were killed and serum bilirubin(BIL) and the amount of nitric oxide(NO) in intestinal tissue were determined,the morphological changes of the intestine were observed,the villus height and mucosal thickness were measured.Results Compared with group A,the serum BIL and the amount of NO in intestinal tissue were increased and the villus height and mucosal thickness were reduced in group B(P0.05) compared with group A.Conclusion Glycine can decrease the level of NO in the intestinal tissue and improve the damaged intestinal barrier obviously.